Phosphoinositides modulate a plethora of functions including signal transduction and membrane trafficking. PtdInsPs are thought to consist of seven interconvertible species that localize to a specific organelle, to which they recruit a set of cognate effector proteins. Here, in reviewing the literature, we argue that this model needs revision. First, PtdInsPs can carry a variety of acyl chains, greatly boosting their molecular diversity. Second, PtdInsPs are more promiscuous in their localization than is usually acknowledged. Third, PtdInsP interconversion is likely achieved (...) through kinase-phosphatase enzyme complexes that coordinate their activities and channel substrates without affecting bulk substrate population. Additionally, we contend that despite hundreds of PtdInsP effectors, our attention is biased toward few proteins. Lastly, we recognize that PtdInsPs can act to nucleate coincidence detection at the effector level, as in PDK1 and Akt. Overall, better integrated models of PtdInsP regulation and function are not only possible but needed. Phosphoinositides are lipids that control many cellular functions. However, the field of PtdInsP signaling is dominated by several dogmatic notions. Here, we offer an updated glimpse on the current state of the field regarding molecular diversity, localization, organization of modifying enzymes, effector types, and effector organization. (shrink)

As physicians, the supreme importance of health and its integral role in any individual’s pursuit of life, liberty and happiness is exhibited on a daily basis. It is abundantly clear that without h...

Stephen Davies taught philosophy at the University of Auckland, Auckland, New Zealand. His research specialty is the philosophy of art. He is a former President of the American Society for Aesthetics. His books include Definitions of Art (Cornell UP, 1991), Musical Meaning and Expression (Cornell UP, 1994), Musical Works and Performances (Clarendon, 2001), Themes in the Philosophy of Music (OUP, 2003), Philosophical Perspectives on Art (OUP, 2007), Musical Understandings and Other Essays on the Philosophy of Music (OUP, 2011), The Artful (...) Species: Aesthetics, Art, and Evolution (OUP, 2012), The Philosophy of Art (Wiley-Blackwell, 2016 second ed.), and Adornment: What Self-decorations Tells Us about Who We Are, (Bloomsbury Academic, 2020). (shrink)

As a scientific, materialist worldview becomes increasingly difficult to repudiate, and as philosophers increasingly uncover and articulate the conceptual nature of morality and distinctively moral normativity, the threat of moral anti-realism becomes more and more real. This perspective is argued in Chapter One. Chapter Two discusses how laws and bioethical trends that pertain to the clinical management of patients in a vegetative coma differ from country to country and continue to give rise to unresolved legal debates and scientific controversy. Chapter (...) Three covers how caregivers in palliative care must be supported to better understand patients hopes and needs, making them comfortable to decide when or how much they want to eat. Chapter Four synthesises findings from four empirical studies conducted in Western Africa (Togo) on topics related to the autonomy (end of life decision-making among terminally-ill patients), benevolence and non-malevolence (breaking bad news to elderly patients and their families), and justice (informal payments to physicians, criminal prosecution in cases of HIV transmission) principles of bioethics. Finally, Chapter Five argues that expert members in Ethics committees have an unfair upper-hand, with their decisions trumping other debates in committee deliberations. Qualitative research is brought to bear which illustrates this and which also notes how expertise dilutes the training given to newly appointed ethics committee members. (shrink)

Spatial region concepts such as “front,” “back,” “left,” and “right” reflect our typical interaction with space, and the corresponding surrounding regions have different statuses in memory. We examined the representation of spatial directions in the auditory space, specifically in how far natural response actions, such as orientation movements toward a sound source, would affect the categorization of egocentric auditory space. While standing in the middle of a circle with 16 loudspeakers, participants were presented acoustic stimuli coming from the loudspeakers in (...) randomized order, and verbally described their directions by using the concept labels “front,” “back,” “left,” “right,” “front-right,” “front-left,” “back-right,” and “back-left.” Response actions varied in three blocked conditions: (1) facing front, (2) turning the head and upper body to face the stimulus, and (3) turning the head and upper body plus pointing with the hand and outstretched arm toward the stimulus. In addition to a protocol of the verbal utterances, motion capture and video recording generated a detailed corpus for subsequent analysis of the participants’ behavior. Chi-square tests revealed an effect of response condition for directions within the left and right sides. We conclude that movement-based response actions influence the representation of auditory space, especially within the sides’ regions. Moreover, the representation of auditory space favors the front and the back regions in terms of resolution, which is possibly related to the physiological characteristics of the human auditory system, as well as to the ecological requirements of action control in the different regions. (shrink)

A considerable body of evidence now documents, beyond reasonable doubt, biological and health risk factors for crime and violence. Nevertheless, intervention and prevention efforts with offenders have avoided biological interventions, in part due to past misuses of biological research and the challenges that biological predispositions to crime raise. This article reviews the empirical literature on two biological intervention approaches, omega-3 supplementation and transcranial direct current stimulation. Emerging research on these relatively benign interventions suggests that increased omega-3 intake through dietary intervention (...) and prefrontal upregulation using non-invasive brain stimulation may show some initial promise in reducing antisocial behavior. The ethical issues related to mandated and offered biological interventions within the criminal justice system are discussed. (shrink)

The article proposes looking at children's literature, particularly the form of the picture book, as an educational resource for producing body awareness in school. Eight reading steps for as many bodily actions aimed at naming the body, activating it, getting to know it and moving it in space, on and off the pages; between grounding, listening, breathing, playing and moving, the rediscovery of gestures and anatomical truths invites to deepen self-knowledge as a preliminary act to the encounter and relationship with (...) the other and with the environment. The picture books by their specificities of short form and cross-over, offer, even in non-fiction production, the possibility of bringing attention back to the body dimension within the school and educational debate, where it lives today in a state of malaise and oblivion. Meaningful conversations, explorations and relationships flow from the pages of the albums: research on language as a tool that gives dignity and value to each person, and encounters with the artistic representation of the world as an infinite mirror of its multiplicity and variety, constitute valuable opportunities for an education that is aware of the wholeness of learners and teachers and the integrated, erotic and embodied dimension of their relationship. (shrink)

Evolutionary game theory and public goods games offer an important framework to understand cooperation during pandemics. From this perspective, the COVID-19 situation can be conceptualized as a dilemma where people who neglect safety precautions act as free riders, because they get to enjoy the benefits of decreased health risk from others’ compliance with policies despite not contributing to or even undermining public safety themselves. At the same time, humans appear to carry a suite of evolved psychological mechanisms aimed at curbing (...) free riding in order to ensure the continued provision of public goods, which can be leveraged to develop more effective measures to promote compliance with regulations. We also highlight factors beyond free riding that reduce compliance rates, such as the emergence of conspiratorial thinking, which seriously undermine the effectiveness of measures to suppress free riding. Together, the current paper outlines the social dynamics that occur in public goods dilemmas involving the spread of infectious disease, highlights the utility and limits of evolutionary game-theoretic approaches for COVID-19 management, and suggests novel directions based on emerging challenges to cooperation. (shrink)

Aristotle often describes virtue in an idealized way, indicating that the virtuous person will never err or have a bad desire. Yet, drawing from empirical work on character and personality, many philosophers and psychologists believe that most people’s behavior stems from situational factors and that good behavior often stems from the wrong motives, such as maintaining a good mood or relieving feelings of guilt. Further, some suggest that the variability in most people’s behavior raises a challenge to traditional categories of (...) character such as virtue, vice, continence, and incontinence. Thus, it may seem impossible to develop virtue and that people lack character as Aristotle conceived of it. Drawing from Aristotle’s Rhetoric and Politics, I develop accounts of actual virtue and the character of ordinary people and respond to these two concerns. (shrink)

The globalism objection poses two distinct challenges to Aristotelian views of virtue. On the one hand, the consistency thesis demands that a virtue is behaviorally expressed in a wide range of trait-relevant situations. On the other hand, the evaluative integration thesis suggests that the presence of one virtue increases the probability of other, similar virtues, posing a problem for Aristotle’s reciprocity of the virtues thesis. I show that, by contrast to contemporary Aristotelian views and views attributed to Aristotle, Aristotle’s own (...) theory of virtue escapes the globalism objection. I address the consistency thesis by showing that each of Aristotle’s moral virtues are narrower than commonly assumed. I then address the evaluative integration thesis through a discussion of practical wisdom, showing that Aristotle believed one could fall short of perfect virtue, while still being fully virtuous. The upshot is that, despite idealizations of virtue throughout the Nicomachean Ethics, Aristotle held a realistic account of virtue, one that is different from contemporary Aristotelian views, and one that is empirically adequate insofar as it allows for more than a few virtuous people. (shrink)

This contribution contextualizes the relationship between fragility and education in the light of people’s changing conditions and perspectives, and their impact on educational processes, focusing in particular on the consequences of the outbreak of the Covid-19 pandemic. By doing so, it introduces this focus, illustrates its coherence, and explains the basic methodological choice, namely the adoption of the Systematic Review, to explore different aspects of the relationship between fragility and education.

Previous empirical research has found mixed results for the impact of corporate social responsibility (CSR) investments on corporate financial performance (CFP). This paper contributes to the literature by exploring in a two stage investor decision-making model the relationship between a firm’s innovation effort, CSR, and financial performance. We simultaneously examine the impact of CSR on both accounting-based (financial health) and market-based (Tobin’s Q) financial performance measures. From a sample of top corporate citizens, we find that: (1) a firm’s social responsibility (...) commitment (CSR) contributes to its financial performance; (2) after controlling for investment in innovation activities, CSR continues to have a positive impact on a firm’s financial performance; (3) the customer dimension of CSR has a positive effect on both CFP measures, whereas the employee dimension indicates a significant impact only on financial heath; and (4) the community relation dimension of CSR only affects the market-based CFP measure of firms with high innovation intensity. (shrink)

Increasingly, biologists are using computers to model and to create biological representations. However, the exponential growth in available biological dataposes a challenge for experimental and theoretical researchers in both Biology and in Computer Science. In short, when even the simple retrieval of relevant biological information for a researcher becomes a complex task — its analysis and synthesis with other biological information will become even more daunting and unlikely. In this context, specially organized ‘structures of representation’ are needed for the efficient (...) interpretation of experimentally generated data. The “semantic Web” is a recent trend in networking techniques that we will examine here as a possible strategy for the computation of biological data — one that may allow us to take into account both the semiotic dimensions of biological processes, as well as their dynamic organization into stable and systemic levels. Thereupon, we propose that a semantic network for biology could benefit from principles rooted in such previous representation efforts as computer-generated ‘landscapes’ and ‘physical attractors’ — and that such principles could, in turn, then be better integrated into biological research through the development of a more semiotically informed user / computer interface design. (shrink)

This qualitative classroom study investigated the development of pragmatic competence in academic discussions through content analysis of student reflective writing. The aims of the study were: to understand the greatest challenges that students faced during the learning process, the causes of those challenges, and the most successful strategies that students employed to overcome the challenges. In addition, the analysis investigated other significant themes in the reflective writing that related to the students’ experiences in developing their pragmatic competence in discussions. Five (...) advanced English for Academic Purposes (EAP) students at a Sino-US institution in China participated over the course of a semester. Results showed that common challenges included: hesitation resulting in missed opportunities to speak, lack of clarity when speaking, inability to repair communication breakdowns, and difficulty with listening comprehension. Self-reflection allowed the learners to understand the various reasons for the challenges they faced and to develop appropriate pragmalinguistic and sociopragmatic strategies for coping with them. It also enabled the instructor to make suggestions suited to learners’ specific needs. In addition to revealing specific challenges, causes, and strategies that students employed, themes that emerged through content analysis included the impact of students’ emotional lives on their learning and performance, as well as the value of authentic communication in the development of pragmatic competence for academic discussions. This exploratory classroom investigation provides suggestions for teaching pragmatic competence in academic discussions and for additional classroom explorations that empower learners to develop autonomy. (shrink)

ArgumentFollowing an international trend, Italy has reformed its university system, especially concerning methods and tools for research evaluation, which are increasingly focused on a number of bibliometric indexes. To study the effects of these changes, we analyze the changing profiles of economists who have won competitions for full professorship in the last few decades in the country. We concentrate on individual characteristics and on scientific production. We show that the identification of a univocal and standardized concept of “research quality” within (...) the new research assessments has progressively imposed a strategy of “homologation,” especially for women. We find that women economists are at a higher risk of discrimination than their male colleagues and thus they are more likely to conform their research activities to the standardized profile imposed by the gender-blind application of simplistic bibliometric methods. (shrink)

The tropical rain-forest regions in Borneo Island have in place various tough environmental policies to manage the economic use of natural resources sustainably. Nevertheless, their biological landscapes are struggling against unprecedented ecological assault amid rapid industrial transformations which have involved massive and irreversible exploitation of land resources. The main reason behind this mismatch of sustainable resource management vis-à-vis unsustainable resource use is the failure on the part of the policy makers to act under the guidance of certain ethical virtues when (...) attempting to translate environmental rhetoric in print to concrete actions in reality. Ethical engagement with nature is pivotal in helping to stimulate genuine efforts in environmental conservation. Field research in the Borneo tropical rain-forest state of Sarawak, Malaysia is able to identify and evaluate the distinctive environmental attitudes, values, and practices of the indigenous communities, and their implications on Sarawak’s sustainable land-resource use and to reinforce the importance of ethical leadership in addressing a myriad of today’s environmental challenges. (shrink)

In this article the author examine the type of mobilization processes that occur via interactions between the UNESCO and other political actors, and how these processes led to the creation of standard-setting and monitoring instruments, like the Belèm Framework for Action (UNESCO 2009) and the Global Report on Adult Learning and Education (UIL 2003, 2013). The findings point at three concurrent processes or modes of mobilization in adult education: landmarking, brokering and framing. Landmarking refers to the process of co-constructing a (...) shared past for a broad set of actors with policy will in adult education; Brokering captures the process of supporting the transaction of values, ideas and information to envision a viable future for adult education; finally framing addresses the structuring of information and intentions to produce materials changes at governmental level in the field of adult education. Drawing on different data sources, for each mode the author present and discuss few of its incidences and visible marks. (shrink)

BackgroundCognitive dysfunctions, both subjective and detectable at psychometric testing, may follow SARS-CoV-2 infection. However, the ecological-functional relevance of such objective deficits is currently under-investigated. This study thus aimed at investigating the association between objective cognitive measures and both physical and cognitive, ecological-functional outcomes in post-COVID-19.MethodsForty-two COVID-19-recovered individuals were administered the Mini-Mental State Examination and the Montreal Cognitive Assessment. The Functional Independence Measure was adopted to assess functional-ecological, motor/physical and cognitive outcomes at admission and discharge.ResultsWhen predicting both T0/T1 FIM-total and-Motor scores (...) based on MMSE/MoCA scores, premorbid risk for cognitive decline and disease-related features, no model yielded a significant fit. However, the MoCA - but not the MMSE significantly predicted T0/T1 FIM-Cognitive scores. The MoCA was significantly related only to T0/T1 FIM-Cognitive Memory items.DiscussionCognitive measures are not associated with physical/motor everyday-life outcomes in post-COVID-19 patients. The MoCA may provide an ecological estimate of cognitive functioning in this population. (shrink)

Aim of this study was to investigate whether parental mental representations during pregnancy and after delivery differed between parents who conceived after Assisted Reproductive Treatments and spontaneous conceiving parents. Effects of specific ART variables were also taken into account. Seventeen ART couples and 25 SC couples were recruited at Santa Maria Nuova Hospital. At both 32 weeks of gestation and 3 months postpartum participants completed the Semantic Differential of the IRMAG, a self-report tool which measures specific domains of mental representations (...) pertaining either individual or parental characteristics. Results showed that ART parents had significantly more positive representations of the child compared to SC parents, while the scores at Partner dimension improved from T1 to T2 for SC parents only. With regards to ART history, scores at the Self-as-woman/man dimension were significantly less positive for ICSI than IVF parents and improved substantially from T1 to T2 only in case of mothers with previous ART attempts and of fathers at the first ART cycle. The representation of own parents increased from T1 to T2 in case of infertility diagnosis due to male factors, while a decrease emerged when infertility was due to female factors. Findings suggest the need to investigate parental mental representations after ART, in order to improve the understanding on the transition to parenthood of infertile couples and to target more specific intervention for parenting support. (shrink)

A large and growing body of research in computational psychiatry draws on Bayesian modelling to illuminate the dysfunctions and aberrations that underlie psychiatric disorders. After identifying the chief attractions of this research programme, we argue that its typical focus on abstract, domain-general inferential processes is likely to obscure many of the distinctive ways in which the human mind can break down and malfunction. We illustrate this by appeal to psychosis and the social phenomenology of delusions.

When speaking of the posthistorical, one is also speaking of posthumanism, so that the question becomes “On what basis can one speak in these terms? And what are their main characteristics?” I begin with statements that include these questions, and answer by exploring the theme of negativity put forth by Giorgio Agamben, Emmanuel Levinas, Vladimir Jankélévitch, and Jean-Luc Nancy. Negativity generates negative phenomena and contexts that lead to negative feelings and states of mind. It also includes such phenomena as boredom, (...) solitude, loneliness, and isolation, which I consider in this order to show the similarities and differences among these phenomena and pose the question whether they can influence one another. I conclude by examining whether these phenomena are symptoms of a posthumanist nihilism or if they can bring forth changes in our human, insurmountable finitude. If so, a different ethics arises that sets aside the humanism of the past and puts in its place a posthuman way of being-in-common based on co-existence. (shrink)

A book that divides its sections like Wittgenstein’s Tractatus Logico-Philosophico demands careful reading. Furthermore, the book by Tiziana Andina entitled The Problem of Perception in Nietzsche Philosophy is prefaced by Maurizio Ferraris, who is the Director of a series of studies of The Laboratory for Ontology in Turin. Approaching Andina’s book, one realizes that it is a remarkable work, an important contribution to Nietzsche studies; this is because her scientific and philosophical knowl...

By analyzing the three loci of aesthetics -- the subjective, the objective, and the absolute -- the author concludes that only the sublime demonstrates that art is neither subjective nor objective. The one essential component of art is the new, the sole "instrument" that can guarantee art's vitality even when confronted by the nihilistic tendencies of modernit.